The German physicist Werner Heisenberg (1901-1976) received the Nobel Prize in physics in 1932 for his work in nuclear physics and quantum theory. The paper on the uncertainty relation is his most important contribution to physics.
Heisenberg impressed his teachers with his ambition and brilliance. He never produced other grades than straight A's, except on one occasion: During his doctorate, Professor Wien of the university of Munich gave him an F in experimental physics, because he handled the laboratory equipment clumsily.
Fate has it that a few years later, Heisenberg demonstrated the very limitations of experimental physics, which unquestionably constituted a setback for its advocates, including Professor Wien.